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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Huang, Huiya, Liu, Yiqi, Liao, Weixi, Cao, Yubing, Liu, Qiang, Guo, Yakun, Lu, Yinying, Xie, Zhen
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6805884/
https://ncbi.nlm.nih.gov/pubmed/31641136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12794-2
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