Modification of extracellular matrix enhances oncolytic adenovirus immunotherapy in glioblastoma

PURPOSE: Extracellular matrix (ECM) component hyaluronan (HA) facilitates malignant phenotypes of glioblastoma (GBM), however, whether HA impacts response to GBM immunotherapies is not known. Herein, we investigated whether degradation of HA enhances oncolytic virus immunotherapy for GBM. METHODS: P...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Kiyokawa, Juri, Kawamura, Yoichiro, Ghouse, Shanawaz M., Acar, Simge, Barcin, Erinc, Martínez-Quintanilla, Jordi, Martuza, Robert L., Alemany, Ramon, Rabkin, Samuel D., Shah, Khalid, Wakimoto, Hiroaki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854507/
https://ncbi.nlm.nih.gov/pubmed/33257429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2400
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