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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6805884/ https://ncbi.nlm.nih.gov/pubmed/31641136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12794-2 |
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