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Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
Improving efficacy of oncolytic virotherapy remains challenging due to difficulty increasing specificity and immune responses against cancer and limited understanding of its population dynamics. Here, we construct programmable and modular synthetic gene circuits to control adenoviral replication and...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6805884/ https://ncbi.nlm.nih.gov/pubmed/31641136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12794-2 |
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