CD70 defines a subset of proinflammatory and CNS-pathogenic T(H)1/T(H)17 lymphocytes and is overexpressed in multiple sclerosis

CD70 is the unique ligand of CD27 and is expressed on immune cells only upon activation. Therefore, engagement of the costimulatory CD27/CD70 pathway is solely dependent on upregulation of CD70. However, the T cell-intrinsic effect and function of human CD70 remain underexplored. Herein, we describe...

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Udgivet i:Cell Mol Immunol
Main Authors: Dhaeze, Tessa, Tremblay, Laurence, Lachance, Catherine, Peelen, Evelyn, Zandee, Stephanie, Grasmuck, Camille, Bourbonnière, Lyne, Larouche, Sandra, Ayrignac, Xavier, Rébillard, Rose-Marie, Poirier, Josée, Lahav, Boaz, Duquette, Pierre, Girard, Marc, Moumdjian, Robert, Bouthillier, Alain, Larochelle, Catherine, Prat, Alexandre
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804668/
https://ncbi.nlm.nih.gov/pubmed/30635649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-018-0198-5
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