Sex-dependent factors encoded in the immune compartment dictate relapsing or progressive phenotype in demyelinating disease

TCR(1640) mice, which have a T cell receptor (TCR) directed against MOG(92–106), spontaneously develop experimental autoimmune encephalomyelitis. Female mice mostly develop a relapsing-remitting (RR) course and have a higher incidence of disease, while males most frequently suffer from progressive d...

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Pubblicato in:JCI Insight
Autori principali: Dhaeze, Tessa, Lachance, Catherine, Tremblay, Laurence, Grasmuck, Camille, Bourbonnière, Lyne, Larouche, Sandra, Saint-Laurent, Olivia, Lécuyer, Marc-André, Rébillard, Rose-Marie, Zandee, Stephanie, Prat, Alexandre
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483003/
https://ncbi.nlm.nih.gov/pubmed/30895941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124885
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