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Design, Synthesis, and Biological Evaluation of Novel Thienopyrimidine Derivatives as PI3Kα Inhibitors

Three series of novel thienopyrimidine derivatives 9a–l, 15a–l, and 18a–h were designed and synthesized, and their IC(50) values against four cancer cell lines HepG-2, A549, PC-3, and MCF-7 were evaluated. Most compounds show moderate cytotoxicity against the tested cancer cell lines. The most promi...

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Publicat a:Molecules
Autors principals: Yu, Lide, Wang, Qinqin, Wang, Caolin, Zhang, Binliang, Yang, Zunhua, Fang, Yuanying, Zhu, Wufu, Zheng, Pengwu
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804295/
https://ncbi.nlm.nih.gov/pubmed/31547116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24193422
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