Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers

A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six compounds demonstrated excellent inhibition activ...

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Detalles Bibliográficos
Publicado en:J Enzyme Inhib Med Chem
Main Authors: Wang, Caolin, Xu, Shan, Peng, Liang, Zhang, Bingliang, Zhang, Hong, Hu, Yingying, Zheng, Pengwu, Zhu, Wufu
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6282443/
https://ncbi.nlm.nih.gov/pubmed/30835140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1518957
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