Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR

[Image: see text] This letter describes the construction of conformationally constrained quinazoline analogues. Structure–activity relationship studies led to the identification of the lead compound 9n. Compound 9n exhibits effective in vitro activity against A431(WT,overexpression) and H1975([L858R...

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Détails bibliographiques
Auteurs principaux: Wu, Jianwei, Chen, Wenteng, Xia, Guangxin, Zhang, Jing, Shao, Jiaan, Tan, Biqin, Zhang, Chunchun, Yu, Wanwan, Weng, Qinjie, Liu, Haiyan, Hu, Miao, Deng, Hailin, Hao, Yu, Shen, Jingkang, Yu, Yongping
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2013
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027470/
https://ncbi.nlm.nih.gov/pubmed/24900594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002437
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