Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR

[Image: see text] This letter describes the construction of conformationally constrained quinazoline analogues. Structure–activity relationship studies led to the identification of the lead compound 9n. Compound 9n exhibits effective in vitro activity against A431(WT,overexpression) and H1975([L858R...

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Detalhes bibliográficos
Main Authors: Wu, Jianwei, Chen, Wenteng, Xia, Guangxin, Zhang, Jing, Shao, Jiaan, Tan, Biqin, Zhang, Chunchun, Yu, Wanwan, Weng, Qinjie, Liu, Haiyan, Hu, Miao, Deng, Hailin, Hao, Yu, Shen, Jingkang, Yu, Yongping
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027470/
https://ncbi.nlm.nih.gov/pubmed/24900594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4002437
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