Llwytho...
Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation
Although EGFR is a highly sought-after drug target, inhibitor resistance remains a challenge. As an alternative strategy for kinase inhibition, we sought to explore whether allosteric activation mechanisms could effectively be disrupted. The kinase domain of EGFR forms an atypical asymmetric dimer v...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Bioorg Med Chem |
|---|---|
| Prif Awduron: | , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2017
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5837902/ https://ncbi.nlm.nih.gov/pubmed/28911855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.08.051 |
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