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Design of a selenylsulfide-bridged EGFR dimerization arm mimic
The epidermal growth factor receptor (EGFR) dimerization arm is a key feature that stabilizes dimerization of the extracellular receptor, thereby mediating activation of the tyrosine kinase domain. Peptides mimicking this β-loop feature can disrupt dimer formation and kinase activation, yet these pe...
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| Publicado en: | Bioorg Med Chem |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4451384/ https://ncbi.nlm.nih.gov/pubmed/25840798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.03.040 |
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