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Inhibiting EGFR Dimerization Using Triazolyl-Bridged Dimerization Arm Mimics
The epidermal growth factor receptor (EGFR) is overexpressed in multiple carcinomas and is the focus of a variety of targeted therapies. Here we report the design of peptide-based compounds that mimic the EGFR dimerization arm and inhibit allosteric activation of EGFR. These peptides are modified to...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4366150/ https://ncbi.nlm.nih.gov/pubmed/25790232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118796 |
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