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Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations
Mutational activation of epidermal growth factor receptor (EGFR) in human cancers involves both point mutations and complex mutations (insertions and deletions). In particular, short in-frame insertion mutations within a conserved [Formula: see text] C– [Formula: see text] 4 loop in the EGFR kinase...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6126729/ https://ncbi.nlm.nih.gov/pubmed/30104348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803152115 |
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