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Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations
Mutational activation of epidermal growth factor receptor (EGFR) in human cancers involves both point mutations and complex mutations (insertions and deletions). In particular, short in-frame insertion mutations within a conserved [Formula: see text] C– [Formula: see text] 4 loop in the EGFR kinase...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6126729/ https://ncbi.nlm.nih.gov/pubmed/30104348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803152115 |
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