Design, Synthesis and Biological Evaluation of 6,7-Disubstituted-4-phenoxyquinoline Derivatives Bearing Pyridazinone Moiety as c-Met Inhibitors

Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, a series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing pyridazinone derivative...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Liu, Xiaobo, Kou, Jianlan, Xiao, Zhen, Tian, Fajuan, Hu, Jiayi, Zheng, Pengwu, Zhu, Wufu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099740/
https://ncbi.nlm.nih.gov/pubmed/29949931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071543
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