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Design, Synthesis, and Biological Evaluation of the First c-Met/HDAC Inhibitors Based on Pyridazinone Derivatives

[Image: see text] Simultaneous blockade of more than one pathway is considered to be a promising approach to overcome the low efficacy and acquired resistance of cancer therapies. Thus, a novel series of c-Met/HDAC bifunctional inhibitors was designed and synthesized by merging pharmacophores of c-M...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Lu, Dong, Yan, Juan, Wang, Lang, Liu, Hongchun, Zeng, Limin, Zhang, Minmin, Duan, Wenwen, Ji, Yinchun, Cao, Jingchen, Geng, Meiyu, Shen, Aijun, Hu, Youhong
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554914/
https://ncbi.nlm.nih.gov/pubmed/28835797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00172
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