Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors

Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives. Kinase inhibition, cell proliferation, and whole blood stability assays were used to...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Pharm Sin B
Auteurs principaux: Wu, Xiaowei, Dai, Mengdi, Cui, Rongrong, Wang, Yulan, Li, Chunpu, Peng, Xia, Zhao, Jihui, Wang, Bao, Dai, Yang, Feng, Dan, Yang, Tianbiao, Jiang, Hualiang, Geng, Meiyu, Ai, Jing, Zheng, Mingyue, Liu, Hong
Format: Artigo
Langue:Inglês
Publié: Elsevier 2021
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982429/
https://ncbi.nlm.nih.gov/pubmed/33777682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.09.002
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