Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase

[Image: see text] C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening of an internal kinase inhibitor collection identified pyridazinone lead...

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Publicat a:ACS Med Chem Lett
Autors principals: O’Malley, Daniel P., Ahuja, Vijay, Fink, Brian, Cao, Carolyn, Wang, Cindy, Swanson, Jesse, Wee, Susan, Gavai, Ashvinikumar V., Tokarski, John, Critton, David, Paiva, Anthony A., Johnson, Benjamin M., Szapiel, Nicolas, Xie, Dianlin
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792176/
https://ncbi.nlm.nih.gov/pubmed/31620238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00354
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