Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase

[Image: see text] C-terminal Src kinase (CSK) functions as a negative regulator of T cell activation through inhibitory phosphorylation of LCK, so inhibitors of CSK are of interest as potential immuno-oncology agents. Screening of an internal kinase inhibitor collection identified pyridazinone lead...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: O’Malley, Daniel P., Ahuja, Vijay, Fink, Brian, Cao, Carolyn, Wang, Cindy, Swanson, Jesse, Wee, Susan, Gavai, Ashvinikumar V., Tokarski, John, Critton, David, Paiva, Anthony A., Johnson, Benjamin M., Szapiel, Nicolas, Xie, Dianlin
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792176/
https://ncbi.nlm.nih.gov/pubmed/31620238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00354
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki