Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors

[Image: see text] A series of imidazo[1,2-a]pyridine derivatives against c-Met was designed by means of bioisosteric replacement. In this study, a selective, potent c-Met inhibitor, 22e was identified, with IC(50) values of 3.9 nM against c-Met kinase and 45.0 nM against c-Met-addicted EBC-1 cell pr...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Li, Chunpu, Ai, Jing, Zhang, Dengyou, Peng, Xia, Chen, Xi, Gao, Zhiwei, Su, Yi, Zhu, Wei, Ji, Yinchun, Chen, Xiaoyan, Geng, Meiyu, Liu, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434476/
https://ncbi.nlm.nih.gov/pubmed/26005523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5004876
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