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Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors
[Image: see text] A series of imidazo[1,2-a]pyridine derivatives against c-Met was designed by means of bioisosteric replacement. In this study, a selective, potent c-Met inhibitor, 22e was identified, with IC(50) values of 3.9 nM against c-Met kinase and 45.0 nM against c-Met-addicted EBC-1 cell pr...
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| Vydáno v: | ACS Med Chem Lett |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2015
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4434476/ https://ncbi.nlm.nih.gov/pubmed/26005523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5004876 |
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