Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt

We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors. Our ligand-based approach led to the identification of novel substra...

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Bibliographic Details
Main Authors: Kim, Young B., Kang, Chang Won, Ranatunga, Sujeewa, Yang, Hua, Sebti, Said M., Del Valle, Juan R.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176526/
https://ncbi.nlm.nih.gov/pubmed/25205195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.08.040
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