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Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt
We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors. Our ligand-based approach led to the identification of novel substra...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176526/ https://ncbi.nlm.nih.gov/pubmed/25205195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.08.040 |
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