Solid-Phase Synthesis of Tetrahydropyridazinedione-Constrained Peptides

[Image: see text] The design and solid-phase synthesis of tetrahydropyridazine-3,6-dione (Tpd) peptidomimetics derived from backbone-aminated peptides is reported. The described protocol features the synthesis of chiral α-hydrazino acids suitable for chemoselective incorporation into growing peptide...

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Bibliografiske detaljer
Main Authors: Kang, Chang Won, Ranatunga, Sujeewa, Sarnowski, Matthew P., Del Valle, Juan R.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4201324/
https://ncbi.nlm.nih.gov/pubmed/25295511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol5026684
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