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Mechanisms and prevention of trifluoroacetylation in solid-phase peptide synthesis

A novel mechanism for trifluoroacetylation in solid-phase peptide synthesis, independent of the coupling step, has been elucidated. It involves the presence of trifluoroacetoxymethyl groups on the resin support, which react with resin-bound amines by an intersite nucleophilic reaction. The trifluoro...

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Detaylı Bibliyografya
Asıl Yazarlar: Kent, Stephen B. H., Mitchell, Alexander R., Engelhard, Martin, Merrifield, R. B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1979
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC383561/
https://ncbi.nlm.nih.gov/pubmed/287055
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