Mechanisms and prevention of trifluoroacetylation in solid-phase peptide synthesis
A novel mechanism for trifluoroacetylation in solid-phase peptide synthesis, independent of the coupling step, has been elucidated. It involves the presence of trifluoroacetoxymethyl groups on the resin support, which react with resin-bound amines by an intersite nucleophilic reaction. The trifluoro...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1979
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383561/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/287055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.5.2180 |
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