Mechanisms and prevention of trifluoroacetylation in solid-phase peptide synthesis

A novel mechanism for trifluoroacetylation in solid-phase peptide synthesis, independent of the coupling step, has been elucidated. It involves the presence of trifluoroacetoxymethyl groups on the resin support, which react with resin-bound amines by an intersite nucleophilic reaction. The trifluoro...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kent, Stephen B. H., Mitchell, Alexander R., Engelhard, Martin, Merrifield, R. B.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1979
Soggetti:	Biological Sciences: Biochemistry
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383561/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/287055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.5.2180
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