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Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities
[Image: see text] By repurposing a typical dopamine D(1)/D(5) receptor agonist motif, C1-substituted-N3-benzazepine or benzazecine, into the classical RTK inhibitor 2,4-diaminopyrimidine skeleton, a series of new 2,4-diarylaminopyrimidine analogues (DAAPalogues) were developed. Compounds 7 and 8a we...
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| Glavni autori: | , , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2014
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| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027579/ https://ncbi.nlm.nih.gov/pubmed/24900831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400373j |
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