Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities

[Image: see text] By repurposing a typical dopamine D(1)/D(5) receptor agonist motif, C1-substituted-N3-benzazepine or benzazecine, into the classical RTK inhibitor 2,4-diaminopyrimidine skeleton, a series of new 2,4-diarylaminopyrimidine analogues (DAAPalogues) were developed. Compounds 7 and 8a we...

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Главные авторы: Liu, Zhiqing, Ai, Jing, Peng, Xia, Song, Zilan, Wu, Kui, Zhang, Jing, Yao, Qizheng, Chen, Yi, Ji, Yinchun, Yang, Yanhong, Geng, Meiyu, Zhang, Ao
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027579/
https://ncbi.nlm.nih.gov/pubmed/24900831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400373j
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