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Discovery of Novel c-Met Inhibitors Bearing a 3-Carboxyl Piperidin-2-one Scaffold

A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indicated that five compounds exhibited significa...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Molecules
Main Authors: Zhang, Wei, Ai, Jing, Shi, Dakuo, Peng, Xia, Ji, Yinchun, Liu, Jian, Geng, Meiyu, Li, Yingxia
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271681/
https://ncbi.nlm.nih.gov/pubmed/24566328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules19022655
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