Discovery of novel quinazoline derivatives bearing semicarbazone moiety as potent EGFR kinase inhibitors

Aimed at discovering effective EGFR inhibitors, six series of quinazoline derivatives bearing a semicarbazone moiety were designed, synthesized and evaluated in different cancer cell lines (A549, HepG2, MCF-7 and PC-3). Most of the selected compounds showed remarkable cytotoxicity with IC(50) values...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Tu, Yuanbiao, Wang, Caolin, Yang, Zunhua, Zhao, Bingbing, Lai, Luogen, Yang, Qi, Zheng, Pengwu, Zhu, Wufu
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232652/
https://ncbi.nlm.nih.gov/pubmed/30455856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2018.10.016
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