Discovery of Triazolo-pyridazine/-pyrimidine Derivatives Bearing Aromatic (Heterocycle)-Coupled Azole Units as Class II c-Met Inhibitors

[Image: see text] Two series of novel triazolo-pyridazine/-pyrimidine derivatives were designed, synthesized, and evaluated for their inhibitory activity against c-Met kinase, as well as three c-Met overexpressed cancer cell lines (A549, MCF-7, and HeLa) and one normal human hepatocytes cell line LO...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Zhang, Qian, Liu, Xiaobo, Gan, Wenhui, Wu, Jinjin, Zhou, Hualan, Yang, Zunhua, Zhang, Yiling, Liao, Min, Yuan, Ping, Xu, Shan, Zheng, Pengwu, Zhu, Wufu
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7364574/
https://ncbi.nlm.nih.gov/pubmed/32685812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c00838
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