Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth

Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In the effort to identify anti-TS drugs with new mode...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Pacifico, Salvatore, Santucci, Matteo, Luciani, Rosaria, Saxena, Puneet, Linciano, Pasquale, Ponterini, Glauco, Lauriola, Angela, D’Arca, Domenico, Marverti, Gaetano, Guerrini, Remo, Costi, Maria Paola
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6804113/
https://ncbi.nlm.nih.gov/pubmed/31561530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24193493
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