A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

AIM: The p53 cancer mutation Y220C creates a conformationally unstable protein with a unique elongated surface crevice that can be targeted by molecular chaperones. We report the structure-guided optimization of the carbazole-based stabilizer PK083. MATERIALS & METHODS: Biophysical, cellular and...

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Enregistré dans:
Détails bibliographiques
Publié dans:Future Med Chem
Auteurs principaux: Bauer, Matthias R, Jones, Rhiannon N, Tareque, Raysa K, Springett, Bradley, Dingler, Felix A, Verduci, Lorena, Patel, Ketan J, Fersht, Alan R, Joerger, Andreas C, Spencer, John
Format: Artigo
Langue:Inglês
Publié: Newlands Press Ltd 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803818/
https://ncbi.nlm.nih.gov/pubmed/31633398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2019-0181
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