Small molecule induced reactivation of mutant p53 in cancer cells

The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers. Here, we have identified a compound, PK7088, which is active in vitro: PK7088 bound to t...

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Hlavní autoři: Liu, Xiangrui, Wilcken, Rainer, Joerger, Andreas C., Chuckowree, Irina S., Amin, Jahangir, Spencer, John, Fersht, Alan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Gene Regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695503/
https://ncbi.nlm.nih.gov/pubmed/23630318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt305
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