Identification and characterization of Cardiac Glycosides as senolytic compounds

Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting t...

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Udgivet i:Nat Commun
Main Authors: Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta, Hernández-González, Fernanda, Lalinde, Marta, Prats, Neus, Bernadó, Cristina, González, Patricia, Gómez, María, Ikonomopoulou, Maria P., Fernández-Marcos, Pablo J., García-Caballero, Tomás, del Pino, Pablo, Arribas, Joaquín, Vidal, Anxo, González-Barcia, Miguel, Serrano, Manuel, Loza, María I., Domínguez, Eduardo, Collado, Manuel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803708/
https://ncbi.nlm.nih.gov/pubmed/31636264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12888-x
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