Identification and characterization of Cardiac Glycosides as senolytic compounds

Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions. Here we report the identification of Cardiac Glycosides (CGs) as a family of compounds with senolytic activity. CGs, by targeting t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Triana-Martínez, Francisco, Picallos-Rabina, Pilar, Da Silva-Álvarez, Sabela, Pietrocola, Federico, Llanos, Susana, Rodilla, Verónica, Soprano, Enrica, Pedrosa, Pablo, Ferreirós, Alba, Barradas, Marta, Hernández-González, Fernanda, Lalinde, Marta, Prats, Neus, Bernadó, Cristina, González, Patricia, Gómez, María, Ikonomopoulou, Maria P., Fernández-Marcos, Pablo J., García-Caballero, Tomás, del Pino, Pablo, Arribas, Joaquín, Vidal, Anxo, González-Barcia, Miguel, Serrano, Manuel, Loza, María I., Domínguez, Eduardo, Collado, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803708/
https://ncbi.nlm.nih.gov/pubmed/31636264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12888-x
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