Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging

Aging is characterized by a gradual functional decline of tissues with age. Adult stem and progenitor cells are responsible for tissue maintenance, repair, and regeneration, but during aging, this population of cells is decreased or its activity is reduced, compromising tissue integrity and causing...

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Veröffentlicht in:Aging Cell
Hauptverfasser: Vilas, Jéssica M., Carneiro, Carmen, Da Silva‐Álvarez, Sabela, Ferreirós, Alba, González, Patricia, Gómez, María, Ortega, Sagrario, Serrano, Manuel, García‐Caballero, Tomás, González‐Barcia, Miguel, Vidal, Anxo, Collado, Manuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Short Take
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156495/
https://ncbi.nlm.nih.gov/pubmed/30129215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12834
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