Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

BACKGROUND: Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was to identify molecules to prevent OA by regulating chondrocyte senescence and autophagy. ME...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Nogueira-Recalde, Uxía, Lorenzo-Gómez, Irene, Blanco, Francisco J., Loza, María I., Grassi, Diego, Shirinsky, Valery, Shirinsky, Ivan, Lotz, Martin, Robbins, Paul D., Domínguez, Eduardo, Caramés, Beatriz
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6642320/
https://ncbi.nlm.nih.gov/pubmed/31285188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.06.049
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