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Autophagy Activation by Rapamycin Reduces Severity of Experimental Osteoarthritis

OBJECTIVES: Osteoarthritis (OA) is associated with cell death and extracellular matrix degradation in articular cartilage. Autophagy is an essential cellular homeostasis mechanism that was found to be deficient in aging and OA cartilage. This study determined whether pharmacological inhibition of th...

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Detalhes bibliográficos
Main Authors: Caramés, Beatriz, Hasegawa, Akihiko, Taniguchi, Noboru, Miyaki, Shigeru, Blanco, Francisco J., Lotz, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294168/
https://ncbi.nlm.nih.gov/pubmed/22084394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200557
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