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Autophagy Activation by Rapamycin Reduces Severity of Experimental Osteoarthritis

OBJECTIVES: Osteoarthritis (OA) is associated with cell death and extracellular matrix degradation in articular cartilage. Autophagy is an essential cellular homeostasis mechanism that was found to be deficient in aging and OA cartilage. This study determined whether pharmacological inhibition of th...

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Autors principals: Caramés, Beatriz, Hasegawa, Akihiko, Taniguchi, Noboru, Miyaki, Shigeru, Blanco, Francisco J., Lotz, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294168/
https://ncbi.nlm.nih.gov/pubmed/22084394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200557
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