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Autophagy Activation by Rapamycin Reduces Severity of Experimental Osteoarthritis
OBJECTIVES: Osteoarthritis (OA) is associated with cell death and extracellular matrix degradation in articular cartilage. Autophagy is an essential cellular homeostasis mechanism that was found to be deficient in aging and OA cartilage. This study determined whether pharmacological inhibition of th...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3294168/ https://ncbi.nlm.nih.gov/pubmed/22084394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200557 |
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