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Antimalarial Activity of Human Group IIA Secreted Phospholipase A(2) in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins

The level of human group IIA secreted phospholipase A(2) (hGIIA sPLA(2)) is increased in the plasma of malaria patients, but its role is unknown. In parasite culture with normal plasma, hGIIA is inactive against Plasmodium falciparum, contrasting with hGIIF, hGV, and hGX sPLA(2)s, which readily hydr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Dacheux, Mélanie, Sinou, Véronique, Payré, Christine, Jeammet, Louise, Parzy, Daniel, Grellier, Philippe, Deregnaucourt, Christiane, Lambeau, Gérard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803347/
https://ncbi.nlm.nih.gov/pubmed/31405958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00556-19
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