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Antimalarial Activity of Human Group IIA Secreted Phospholipase A(2) in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins

The level of human group IIA secreted phospholipase A(2) (hGIIA sPLA(2)) is increased in the plasma of malaria patients, but its role is unknown. In parasite culture with normal plasma, hGIIA is inactive against Plasmodium falciparum, contrasting with hGIIF, hGV, and hGX sPLA(2)s, which readily hydr...

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Détails bibliographiques
Publié dans:Infect Immun
Auteurs principaux: Dacheux, Mélanie, Sinou, Véronique, Payré, Christine, Jeammet, Louise, Parzy, Daniel, Grellier, Philippe, Deregnaucourt, Christiane, Lambeau, Gérard
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803347/
https://ncbi.nlm.nih.gov/pubmed/31405958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00556-19
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