Neurotoxicity and other pharmacological activities of the snake venom phospholipase A(2) OS(2): The N-terminal region is more important than enzymatic activity

Several snake venom secreted phospholipases A(2) (sPLA(2)s) including OS(2) exert a variety of pharmacological effects ranging from central neurotoxicity to anti-HIV activity by mechanisms that are not yet fully understood. To conclusively address the role of enzymatic activity and map the key struc...

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Main Authors: Rouault, Morgane, Rash, Lachlan D., Escoubas, Pierre, Boilard, Eric, Bollinger, James, Lomonte, Bruno, Maurin, Thomas, Guillaume, Carole, Canaan, Stéphane, Deregnaucourt, Christiane, Schrével, Joseph, Doglio, Alain, Gutiérrez, José María, Lazdunski, Michel, Gelb, Michael H., Lambeau, Gérard
Format: Artigo
Sprog:Inglês
Udgivet: 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796912/
https://ncbi.nlm.nih.gov/pubmed/16669624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi060217r
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