Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer

Human immunodeficiency virus (HIV-1) entry into cells is mediated by the viral envelope glycoprotein (Env) trimer, which consists of three gp120 exterior glycoproteins and three gp41 transmembrane glycoproteins. When gp120 binds sequentially to the receptors CD4 and CCR5 on the target cell, the meta...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhao, Connie, Princiotto, Amy M., Nguyen, Hanh T., Zou, Shitao, Zhao, Meiqing Lily, Zhang, Shijian, Herschhorn, Alon, Farrell, Mark, Pahil, Karanbir, Melillo, Bruno, Sambasivarao, Somisetti V., Abrams, Cameron, Smith, Amos B., Madani, Navid, Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803283/
https://ncbi.nlm.nih.gov/pubmed/31391272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01197-19
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