Strain-Dependent Activation and Inhibition of Human Immunodeficiency Virus Entry by a Specific PF-68742 Stereoisomer

Human immunodeficiency virus (HIV-1) entry into cells is mediated by the viral envelope glycoprotein (Env) trimer, which consists of three gp120 exterior glycoproteins and three gp41 transmembrane glycoproteins. When gp120 binds sequentially to the receptors CD4 and CCR5 on the target cell, the meta...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Zhao, Connie, Princiotto, Amy M., Nguyen, Hanh T., Zou, Shitao, Zhao, Meiqing Lily, Zhang, Shijian, Herschhorn, Alon, Farrell, Mark, Pahil, Karanbir, Melillo, Bruno, Sambasivarao, Somisetti V., Abrams, Cameron, Smith, Amos B., Madani, Navid, Sodroski, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803283/
https://ncbi.nlm.nih.gov/pubmed/31391272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01197-19
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