A Small-Molecule CD4-Mimetic Compound Protects Bone Marrow–Liver–Thymus Humanized Mice From HIV-1 Infection

BACKGROUND: Small-molecule CD4-mimetic compounds (CD4mc) inhibit human immunodeficiency virus (HIV-1) entry by blocking binding to the CD4 receptor and by premature triggering of the viral envelope glycoprotein (Env) spike. METHODS: The efficacy of a CD4mc in protecting bone marrow–liver–thymus (BLT...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Princiotto, Amy M, Vrbanac, Vladimir D, Melillo, Bruno, Park, Jongwoo, Tager, Andrew M, Smith, Amos B, Sodroski, Joseph, Madani, Navid
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6049021/
https://ncbi.nlm.nih.gov/pubmed/29617845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy174
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