A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge

The envelope glycoprotein (Env) trimer ((gp120/gp41)(3)) mediates human immunodeficiency virus (HIV-1) entry into cells. The “closed,” antibody-resistant Env trimer is driven to more open conformations by binding the host receptor, CD4. Broadly neutralizing antibodies that recognize conserved elemen...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Madani, Navid, Princiotto, Amy M., Mach, Linh, Ding, Shilei, Prevost, Jérémie, Richard, Jonathan, Hora, Bhavna, Sutherland, Laura, Zhao, Connie A., Conn, Brandon P., Bradley, Todd, Moody, M. Anthony, Melillo, Bruno, Finzi, Andrés, Haynes, Barton F., Smith III, Amos B., Santra, Sampa, Sodroski, Joseph
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006336/
https://ncbi.nlm.nih.gov/pubmed/29915222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04758-9
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