A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge

The envelope glycoprotein (Env) trimer ((gp120/gp41)(3)) mediates human immunodeficiency virus (HIV-1) entry into cells. The “closed,” antibody-resistant Env trimer is driven to more open conformations by binding the host receptor, CD4. Broadly neutralizing antibodies that recognize conserved elemen...

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Pubblicato in:Nat Commun
Autori principali: Madani, Navid, Princiotto, Amy M., Mach, Linh, Ding, Shilei, Prevost, Jérémie, Richard, Jonathan, Hora, Bhavna, Sutherland, Laura, Zhao, Connie A., Conn, Brandon P., Bradley, Todd, Moody, M. Anthony, Melillo, Bruno, Finzi, Andrés, Haynes, Barton F., Smith III, Amos B., Santra, Sampa, Sodroski, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006336/
https://ncbi.nlm.nih.gov/pubmed/29915222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04758-9
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