A CD4-mimetic compound enhances vaccine efficacy against stringent immunodeficiency virus challenge

The envelope glycoprotein (Env) trimer ((gp120/gp41)(3)) mediates human immunodeficiency virus (HIV-1) entry into cells. The “closed,” antibody-resistant Env trimer is driven to more open conformations by binding the host receptor, CD4. Broadly neutralizing antibodies that recognize conserved elemen...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Madani, Navid, Princiotto, Amy M., Mach, Linh, Ding, Shilei, Prevost, Jérémie, Richard, Jonathan, Hora, Bhavna, Sutherland, Laura, Zhao, Connie A., Conn, Brandon P., Bradley, Todd, Moody, M. Anthony, Melillo, Bruno, Finzi, Andrés, Haynes, Barton F., Smith III, Amos B., Santra, Sampa, Sodroski, Joseph
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006336/
https://ncbi.nlm.nih.gov/pubmed/29915222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04758-9
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