Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conf...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Zou, Shitao, Zhang, Shijian, Gaffney, Althea, Ding, Haitao, Lu, Maolin, Grover, Jonathan R., Farrell, Mark, Nguyen, Hanh T., Zhao, Connie, Anang, Saumya, Zhao, Meiqing, Mohammadi, Mohammadjavad, Blanchard, Scott C., Abrams, Cameron, Madani, Navid, Mothes, Walther, Kappes, John C., Smith, Amos B., Sodroski, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199401/
https://ncbi.nlm.nih.gov/pubmed/32161177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00148-20
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