Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conf...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Zou, Shitao, Zhang, Shijian, Gaffney, Althea, Ding, Haitao, Lu, Maolin, Grover, Jonathan R., Farrell, Mark, Nguyen, Hanh T., Zhao, Connie, Anang, Saumya, Zhao, Meiqing, Mohammadi, Mohammadjavad, Blanchard, Scott C., Abrams, Cameron, Madani, Navid, Mothes, Walther, Kappes, John C., Smith, Amos B., Sodroski, Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199401/
https://ncbi.nlm.nih.gov/pubmed/32161177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00148-20
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