Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conf...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zou, Shitao, Zhang, Shijian, Gaffney, Althea, Ding, Haitao, Lu, Maolin, Grover, Jonathan R., Farrell, Mark, Nguyen, Hanh T., Zhao, Connie, Anang, Saumya, Zhao, Meiqing, Mohammadi, Mohammadjavad, Blanchard, Scott C., Abrams, Cameron, Madani, Navid, Mothes, Walther, Kappes, John C., Smith, Amos B., Sodroski, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199401/
https://ncbi.nlm.nih.gov/pubmed/32161177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00148-20
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