Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conf...

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Veröffentlicht in:J Virol
Hauptverfasser: Zou, Shitao, Zhang, Shijian, Gaffney, Althea, Ding, Haitao, Lu, Maolin, Grover, Jonathan R., Farrell, Mark, Nguyen, Hanh T., Zhao, Connie, Anang, Saumya, Zhao, Meiqing, Mohammadi, Mohammadjavad, Blanchard, Scott C., Abrams, Cameron, Madani, Navid, Mothes, Walther, Kappes, John C., Smith, Amos B., Sodroski, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2020
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199401/
https://ncbi.nlm.nih.gov/pubmed/32161177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00148-20
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