Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins

During human immunodeficiency virus type 1 (HIV-1) entry into cells, the viral envelope glycoprotein (Env) trimer [(gp120/gp41)(3)] binds the receptors CD4 and CCR5 and fuses the viral and cell membranes. CD4 binding changes Env from a pretriggered (state-1) conformation to more open downstream conf...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Virol
Κύριοι συγγραφείς: Zou, Shitao, Zhang, Shijian, Gaffney, Althea, Ding, Haitao, Lu, Maolin, Grover, Jonathan R., Farrell, Mark, Nguyen, Hanh T., Zhao, Connie, Anang, Saumya, Zhao, Meiqing, Mohammadi, Mohammadjavad, Blanchard, Scott C., Abrams, Cameron, Madani, Navid, Mothes, Walther, Kappes, John C., Smith, Amos B., Sodroski, Joseph
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2020
Θέματα:
Vaccines and Antiviral Agents
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7199401/
https://ncbi.nlm.nih.gov/pubmed/32161177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00148-20
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