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Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles

[Image: see text] N3-Methyl-2′-deoxyadenosine (MdA) is the major dA methylation product in duplex DNA. MdA blocks DNA replication and undergoes depurination at significantly higher rates than the native nucleotide from which it is derived. Recent reports on the effects of the nucleosome core particl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Chem Res Toxicol
Hauptverfasser: Yang, Kun, Sun, Huabing, Lowder, Leah, Varadarajan, Sridhar, Greenberg, Marc M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803048/
https://ncbi.nlm.nih.gov/pubmed/31565933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00299
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