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Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles

[Image: see text] N3-Methyl-2′-deoxyadenosine (MdA) is the major dA methylation product in duplex DNA. MdA blocks DNA replication and undergoes depurination at significantly higher rates than the native nucleotide from which it is derived. Recent reports on the effects of the nucleosome core particl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chem Res Toxicol
Egile Nagusiak: Yang, Kun, Sun, Huabing, Lowder, Leah, Varadarajan, Sridhar, Greenberg, Marc M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2019
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803048/
https://ncbi.nlm.nih.gov/pubmed/31565933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00299
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