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Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles

[Image: see text] N3-Methyl-2′-deoxyadenosine (MdA) is the major dA methylation product in duplex DNA. MdA blocks DNA replication and undergoes depurination at significantly higher rates than the native nucleotide from which it is derived. Recent reports on the effects of the nucleosome core particl...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Yang, Kun, Sun, Huabing, Lowder, Leah, Varadarajan, Sridhar, Greenberg, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6803048/
https://ncbi.nlm.nih.gov/pubmed/31565933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00299
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